RTI Biologics, Inc.
Timeline of Innovation

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A History of Innovation

RTI Biologics, Inc. began operations in February 1998, when the University of Florida Tissue Bank, Inc. (UFTB, now called Southeast Tissue Alliance) transferred its allograft processing operations, related equipment and technologies, distribution arrangements and research and development activities to RTI.

Since the company's founding, RTI has grown to become one of the leaders in tissue-based innovations for the repair and natural healing of human bone and other human tissues. RTI is one of the largest processors of precision-tooled biologics in the United States.

In March 2000, RTI made history in the allograft industry by developing BioCleanse®, the first process to use a low-temperature chemical sterilization system that eliminates bacteria, fungi, spores and viruses from tissue without compromising the biocompatibility or structural integrity of the tissue.

In August 2000, RTI completed an initial public offering and began trading on the NASDAQ exchange under the trading symbol RTIX. With the funding from its IPO, RTI was able to improve its facilities to meet pharmaceutical standards and continue developments to improve its processes and implants.

In May 2002, RTI opened its new state-of-the-art facility to better ensure the safety and quality of its implants and to provide greater efficiency in its operations. With the new facility, RTI was able to create the Next-Generation BioCleanse® Tissue Sterilization Process, using multiple chambers to allow tissue from a single donor to be sterilized efficiently. In June 2004, RTI announced the implementation of BioCleanse to sterilize soft tissue implants. To date, more than half a million implants have been sterilized with ZERO incidence of infection.

In 2005, RTI once again led the evolution of biologics by introducing the Sterling® line of implants. These implants are based on bovine tissue from an exclusive, closed heard and optimized through our proprietary BioCleanse process.

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